{"title":"Cognitive \u0026 Focus","description":null,"products":[{"product_id":"semax-30-mg","title":"Semax — 30 mg","description":"\u003ch2\u003eWhat is Semax\u003c\/h2\u003e\n\u003cp\u003eSemax is a synthetic heptapeptide developed in the Soviet Union and later registered as a pharmaceutical in Russia. Its first four residues, Met-Glu-His-Phe, reproduce the 4–7 fragment of adrenocorticotropic hormone. The remaining three, Pro-Gly-Pro, are not part of the ACTH sequence. They were appended specifically to slow enzymatic clearance, and they do — though the parent peptide's plasma half-life is still measured in minutes, because the N-terminal methionine is readily removed by aminopeptidases.\u003c\/p\u003e\n\u003cp\u003eThat design makes Semax a useful object of study in two directions at once. As an ACTH fragment analog it retains the melanocortin-derived sequence while lacking the corticotropic portion of the parent hormone, which allows the two functions to be separated in receptor and gene-expression models. As a prodrug-like structure it generates Pro-Gly-Pro, a fragment with its own documented activity and a longer tissue residence than the intact peptide, so metabolite chemistry is an experimental variable rather than a nuisance. Most published mechanistic work is transcriptomic, examining expression changes in rat brain tissue and cultured glial preparations.\u003c\/p\u003e\n\u003ch2\u003eResearch applications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eNeurotrophin gene expression assays (BDNF, NGF) in cultured glial and neuronal preparations\u003c\/li\u003e\n\u003cli\u003eBDNF\/TrkB signaling pathway modeling in hippocampal tissue preparations\u003c\/li\u003e\n\u003cli\u003eGenome-wide transcriptional profiling of immune and vascular gene response in rodent focal ischemia models\u003c\/li\u003e\n\u003cli\u003eMelanocortin receptor binding and selectivity studies against full-length ACTH reference standards\u003c\/li\u003e\n\u003cli\u003ePeptide metabolism studies characterizing aminopeptidase cleavage kinetics and Pro-Gly-Pro fragment generation\u003c\/li\u003e\n\u003cli\u003eMethionine oxidation and stability-indicating HPLC method development for sulfur-containing peptides\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eVerification\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eEvery lot is tested twice, by two labs, and you can pull the results yourself.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePuritas synthesizes and compounds in its own Florida facility. Domestic synthesis is not a shipping-speed feature. It is control of the contamination chain — we know what went into the reactor, who ran the lyophilizer, and what the room was doing at the time.\u003c\/p\u003e\n\u003cp\u003eEvery lot goes to two independent laboratories:\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003eA US laboratory accredited to ISO\/IEC 17025 for the full analytical panel.\u003c\/li\u003e\n\u003cli\u003eJanoshik Analytical, whose results are published to a public lookup portal.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003eThe lot number is printed on the vial label. Enter it at the testing lab's own portal and the report loads from their database, under their control, with their timestamp.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWe don't host our COAs. Verify them at the lab.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eA hosted PDF is a file a vendor can edit. A record in an accredited lab's system is not.\u003c\/p\u003e\n\u003ch3\u003eThe panel we publish for every lot\u003c\/h3\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eTest\u003c\/th\u003e\n\u003cth\u003eMethod\u003c\/th\u003e\n\u003cth\u003eWhat gets published\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eIdentity\u003c\/td\u003e\n\u003ctd\u003eLC-MS\u003c\/td\u003e\n\u003ctd\u003eMeasured monoisotopic \/ average mass against theoretical\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePurity\u003c\/td\u003e\n\u003ctd\u003eRP-HPLC, UV area normalization\u003c\/td\u003e\n\u003ctd\u003eChromatogram plus numeric % main peak\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSecondary structure \/ functional group confirmation\u003c\/td\u003e\n\u003ctd\u003eFTIR\u003c\/td\u003e\n\u003ctd\u003eSpectrum\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFill accuracy\u003c\/td\u003e\n\u003ctd\u003eGravimetric, per-vial\u003c\/td\u003e\n\u003ctd\u003eMeasured mg, not \"as labeled\"\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEndotoxin\u003c\/td\u003e\n\u003ctd\u003eKinetic chromogenic LAL, USP \u0026lt;85\u0026gt;\u003c\/td\u003e\n\u003ctd\u003eEU\/vial as a number\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHeavy metals\u003c\/td\u003e\n\u003ctd\u003eICP-MS, USP \u0026lt;232\u0026gt;\u003c\/td\u003e\n\u003ctd\u003eMeasured values in ppm for each element, not \"complies\"\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eResidual solvents\u003c\/td\u003e\n\u003ctd\u003eGC-HS\u003c\/td\u003e\n\u003ctd\u003eMeasured values\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWater content\u003c\/td\u003e\n\u003ctd\u003eKarl Fischer\u003c\/td\u003e\n\u003ctd\u003e% w\/w\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCounterion \/ residual TFA\u003c\/td\u003e\n\u003ctd\u003eIon chromatography\u003c\/td\u003e\n\u003ctd\u003e% w\/w after acetate salt exchange\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eFill accuracy and endotoxin are the two numbers most vendors omit. A vial can be 99.4% pure and contain 7.1 mg where the label says 10 mg. Purity is a ratio. Fill is a quantity. They are different failures and we report both.\u003c\/p\u003e\n\u003ch3\u003eFailures stay up\u003c\/h3\u003e\n\u003cp\u003eIf a lot fails specification, the failed report is published with the failure marked, and the lot is destroyed rather than sold. We do not delete reports. We do not renumber lots. We do not requalify a failed lot under a new number. The archive is append-only, and older lots remain retrievable after they sell out.\u003c\/p\u003e\n\u003cp\u003eIf a report you expect to find is missing, that is a defect on our side. Send us the lot number.\u003c\/p\u003e\n\u003ch2\u003eThe Bad Vial Guarantee\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eIf it doesn't reconstitute clear, we replace it or refund it.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSend a photograph of the vial with the lot number legible. That is the entire process. There is no appeal, no review board, no restocking fee, no requirement that you return the vial, and no requirement that you explain what you were doing.\u003c\/p\u003e\n\u003cp\u003eThe guarantee covers:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCloudy, hazy, particulate, or discolored solution on reconstitution.\u003c\/strong\u003e Replacement or refund, your choice.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCracked, chipped, or leaking vials.\u003c\/strong\u003e Same terms.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCompromised stopper or seal, or a vacuum that has failed.\u003c\/strong\u003e Same terms.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBroken in transit.\u003c\/strong\u003e Photograph the package and the contents. Same terms.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLost in transit.\u003c\/strong\u003e If tracking shows no movement for seven days, or shows delivered and it was not, we reship. We do not require a carrier investigation to close first.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAssay disagreement.\u003c\/strong\u003e If you run the material and your numbers materially disagree with the published lot report, send us your data. We will retest and, if you are right, refund the lot, publish the correction, and pull remaining stock.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThere is no time window shorter than the product's shelf life. There is no limit on how many times you can claim. If we conclude a customer is claiming in bad faith we will stop selling to them, and we will say so directly rather than quietly denying claims.\u003c\/p\u003e\n\u003cp\u003eWe would rather eat the cost of a vial than argue about one.\u003c\/p\u003e\n\u003ch2\u003eStorage \u0026amp; handling\u003c\/h2\u003e\n\u003ch3\u003eLyophilized material, sealed vial\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eLong-term: −20 °C, desiccated, protected from light.\u003c\/li\u003e\n\u003cli\u003eShort-term and in-transit: 2–8 °C is acceptable. Ambient exposure during shipping does not compromise a lyophilized peptide over normal transit intervals; these compounds are shipped without cold chain by every laboratory supplier for this reason.\u003c\/li\u003e\n\u003cli\u003eKeep the vial sealed until use. Lyophilized peptide is hygroscopic and water uptake is the primary degradation pathway for dry material.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eAfter reconstitution\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e2–8 °C, protected from light.\u003c\/li\u003e\n\u003cli\u003eDo not freeze-thaw repeatedly. If material must be held long-term in solution, aliquot once and freeze the aliquots at −20 °C or below.\u003c\/li\u003e\n\u003cli\u003eDiscard any solution that develops haze, particulate, color change, or visible precipitate.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eAllow vials to equilibrate to room temperature before opening to avoid condensation onto the dry cake.\u003c\/li\u003e\n\u003cli\u003eDo not vortex or sonicate peptide solutions aggressively. Mechanical shear and foaming drive aggregation.\u003c\/li\u003e\n\u003cli\u003eWork under conditions appropriate to the endotoxin specification you require. Our EU\/vial figure describes the material as shipped, not the material after it has been through your bench.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eShelf life\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e36 months from date of manufacture, lyophilized, at −20 °C.\u003c\/li\u003e\n\u003cli\u003e24 months from date of manufacture, lyophilized, at 2–8 °C.\u003c\/li\u003e\n\u003cli\u003eManufacture date and expiry are printed on the vial label alongside the lot number.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eScientific references\u003c\/h2\u003e\n\u003cp\u003ePublished literature is indexed here for scientific reference. Citation does not indicate that this material is intended for, or suitable for, any use described in these papers.\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003eShadrina MI, et al. Rapid induction of neurotrophin mRNAs in rat glial cell cultures by Semax, an adrenocorticotropic hormone analog. \u003cem\u003eNeuroscience Letters\u003c\/em\u003e. 2001;308(2):115–118. PMID 11457573. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11457573\/\" target=\"_blank\" rel=\"noopener nofollow\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/11457573\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eDolotov OV, et al. Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. \u003cem\u003eBrain Research\u003c\/em\u003e. 2006;1117(1):54–60. PMID 16996037. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16996037\/\" target=\"_blank\" rel=\"noopener nofollow\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/16996037\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eMedvedeva EV, et al. The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis. \u003cem\u003eBMC Genomics\u003c\/em\u003e. 2014;15:228. PMID 24661604. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24661604\/\" target=\"_blank\" rel=\"noopener nofollow\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/24661604\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eMedvedeva EV, et al. Semax, an analog of ACTH(4-7), regulates expression of immune response genes during ischemic brain injury in rats. \u003cem\u003eMolecular Genetics and Genomics\u003c\/em\u003e. 2017;292(3):635–653. PMID 28255762. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28255762\/\" target=\"_blank\" rel=\"noopener nofollow\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/28255762\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"Puritas Lab","offers":[{"title":"Default Title","offer_id":50892719456292,"sku":"PUR-SEM-30","price":89.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0793\/7363\/1524\/files\/puritas-semax-30mg-v2.png?v=1785803353"}],"url":"https:\/\/puritaslab.com\/collections\/cognitive-focus.oembed","provider":"Puritas Lab","version":"1.0","type":"link"}