{"title":"Compounds","description":"\u003cp\u003eEvery compound we synthesize, fill, and release. Each one ships with a printed lot number that resolves to its full release panel in the Lot Ledger.\u003c\/p\u003e","products":[{"product_id":"bpc-157-5-mg","title":"BPC-157 — 5 mg","description":"\u003ch2\u003eWhat is BPC-157\u003c\/h2\u003e\n\u003cp\u003eBPC-157 is a synthetic 15-amino-acid peptide corresponding to a partial sequence of Body Protection Compound, a protein isolated from human gastric juice. Its composition is structurally unusual: four of fifteen residues are proline, giving the backbone considerable conformational rigidity, and the sequence contains no cysteine and therefore forms no disulfide bonds. That combination is the reason it is studied as a model of proteolytic resistance — it is reported to remain intact in human gastric juice for more than 24 hours, which very few peptides of this length do.\u003c\/p\u003e\n\u003cp\u003eIn laboratory research it is used as a probe compound in cytoprotection and angiogenesis-signaling models. Published mechanistic work concentrates on interactions with the nitric oxide system, on VEGFR2 and downstream signaling in endothelial cell models, and on gene expression profiling in cultured fibroblast and tenocyte lines. Its short circulating half-life relative to its persistence in gastric fluid makes it a frequent subject of stability and metabolism method development.\u003c\/p\u003e\n\u003ch2\u003eResearch applications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eIn vitro cytoprotection assay models in gastric and endothelial cell lines\u003c\/li\u003e\n\u003cli\u003eNitric oxide system modulation studies, including L-NAME and L-arginine co-treatment designs\u003c\/li\u003e\n\u003cli\u003eVEGFR2 signaling pathway and endothelial tube-formation modeling\u003c\/li\u003e\n\u003cli\u003eFibroblast and tenocyte outgrowth, adhesion, and migration assays in culture\u003c\/li\u003e\n\u003cli\u003eProteolytic stability and enzymatic degradation profiling in simulated gastric and intestinal fluid\u003c\/li\u003e\n\u003cli\u003eAnalytical method development: LC-MS\/MS quantitation and stability-indicating HPLC method validation\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eVerification\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eEvery lot is tested twice, by two labs, and you can pull the results yourself.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePuritas synthesizes and compounds in its own Florida facility. Domestic synthesis is not a shipping-speed feature. It is control of the contamination chain — we know what went into the reactor, who ran the lyophilizer, and what the room was doing at the time.\u003c\/p\u003e\n\u003cp\u003eEvery lot goes to two independent laboratories:\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003eA US laboratory accredited to ISO\/IEC 17025 for the full analytical panel.\u003c\/li\u003e\n\u003cli\u003eJanoshik Analytical, whose results are published to a public lookup portal.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003eThe lot number is printed on the vial label. Enter it at the testing lab's own portal and the report loads from their database, under their control, with their timestamp.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWe don't host our COAs. Verify them at the lab.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eA hosted PDF is a file a vendor can edit. A record in an accredited lab's system is not.\u003c\/p\u003e\n\u003ch3\u003eThe panel we publish for every lot\u003c\/h3\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eTest\u003c\/th\u003e\n\u003cth\u003eMethod\u003c\/th\u003e\n\u003cth\u003eWhat gets published\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eIdentity\u003c\/td\u003e\n\u003ctd\u003eLC-MS\u003c\/td\u003e\n\u003ctd\u003eMeasured monoisotopic \/ average mass against theoretical\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePurity\u003c\/td\u003e\n\u003ctd\u003eRP-HPLC, UV area normalization\u003c\/td\u003e\n\u003ctd\u003eChromatogram plus numeric % main peak\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSecondary structure \/ functional group confirmation\u003c\/td\u003e\n\u003ctd\u003eFTIR\u003c\/td\u003e\n\u003ctd\u003eSpectrum\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFill accuracy\u003c\/td\u003e\n\u003ctd\u003eGravimetric, per-vial\u003c\/td\u003e\n\u003ctd\u003eMeasured mg, not \"as labeled\"\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEndotoxin\u003c\/td\u003e\n\u003ctd\u003eKinetic chromogenic LAL, USP \u0026lt;85\u0026gt;\u003c\/td\u003e\n\u003ctd\u003eEU\/vial as a number\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHeavy metals\u003c\/td\u003e\n\u003ctd\u003eICP-MS, USP \u0026lt;232\u0026gt;\u003c\/td\u003e\n\u003ctd\u003eMeasured values in ppm for each element, not \"complies\"\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eResidual solvents\u003c\/td\u003e\n\u003ctd\u003eGC-HS\u003c\/td\u003e\n\u003ctd\u003eMeasured values\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWater content\u003c\/td\u003e\n\u003ctd\u003eKarl Fischer\u003c\/td\u003e\n\u003ctd\u003e% w\/w\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCounterion \/ residual TFA\u003c\/td\u003e\n\u003ctd\u003eIon chromatography\u003c\/td\u003e\n\u003ctd\u003e% w\/w after acetate salt exchange\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eFill accuracy and endotoxin are the two numbers most vendors omit. A vial can be 99.4% pure and contain 7.1 mg where the label says 10 mg. Purity is a ratio. Fill is a quantity. They are different failures and we report both.\u003c\/p\u003e\n\u003ch3\u003eFailures stay up\u003c\/h3\u003e\n\u003cp\u003eIf a lot fails specification, the failed report is published with the failure marked, and the lot is destroyed rather than sold. We do not delete reports. We do not renumber lots. We do not requalify a failed lot under a new number. The archive is append-only, and older lots remain retrievable after they sell out.\u003c\/p\u003e\n\u003cp\u003eIf a report you expect to find is missing, that is a defect on our side. Send us the lot number.\u003c\/p\u003e\n\u003ch2\u003eThe Bad Vial Guarantee\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eIf it doesn't reconstitute clear, we replace it or refund it.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSend a photograph of the vial with the lot number legible. That is the entire process. There is no appeal, no review board, no restocking fee, no requirement that you return the vial, and no requirement that you explain what you were doing.\u003c\/p\u003e\n\u003cp\u003eThe guarantee covers:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCloudy, hazy, particulate, or discolored solution on reconstitution.\u003c\/strong\u003e Replacement or refund, your choice.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCracked, chipped, or leaking vials.\u003c\/strong\u003e Same terms.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCompromised stopper or seal, or a vacuum that has failed.\u003c\/strong\u003e Same terms.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBroken in transit.\u003c\/strong\u003e Photograph the package and the contents. Same terms.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLost in transit.\u003c\/strong\u003e If tracking shows no movement for seven days, or shows delivered and it was not, we reship. We do not require a carrier investigation to close first.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAssay disagreement.\u003c\/strong\u003e If you run the material and your numbers materially disagree with the published lot report, send us your data. We will retest and, if you are right, refund the lot, publish the correction, and pull remaining stock.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThere is no time window shorter than the product's shelf life. There is no limit on how many times you can claim. If we conclude a customer is claiming in bad faith we will stop selling to them, and we will say so directly rather than quietly denying claims.\u003c\/p\u003e\n\u003cp\u003eWe would rather eat the cost of a vial than argue about one.\u003c\/p\u003e\n\u003ch2\u003eStorage \u0026amp; handling\u003c\/h2\u003e\n\u003ch3\u003eLyophilized material, sealed vial\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eLong-term: −20 °C, desiccated, protected from light.\u003c\/li\u003e\n\u003cli\u003eShort-term and in-transit: 2–8 °C is acceptable. Ambient exposure during shipping does not compromise a lyophilized peptide over normal transit intervals; these compounds are shipped without cold chain by every laboratory supplier for this reason.\u003c\/li\u003e\n\u003cli\u003eKeep the vial sealed until use. Lyophilized peptide is hygroscopic and water uptake is the primary degradation pathway for dry material.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eAfter reconstitution\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e2–8 °C, protected from light.\u003c\/li\u003e\n\u003cli\u003eDo not freeze-thaw repeatedly. If material must be held long-term in solution, aliquot once and freeze the aliquots at −20 °C or below.\u003c\/li\u003e\n\u003cli\u003eDiscard any solution that develops haze, particulate, color change, or visible precipitate.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eAllow vials to equilibrate to room temperature before opening to avoid condensation onto the dry cake.\u003c\/li\u003e\n\u003cli\u003eDo not vortex or sonicate peptide solutions aggressively. Mechanical shear and foaming drive aggregation.\u003c\/li\u003e\n\u003cli\u003eWork under conditions appropriate to the endotoxin specification you require. Our EU\/vial figure describes the material as shipped, not the material after it has been through your bench.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eShelf life\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e36 months from date of manufacture, lyophilized, at −20 °C.\u003c\/li\u003e\n\u003cli\u003e24 months from date of manufacture, lyophilized, at 2–8 °C.\u003c\/li\u003e\n\u003cli\u003eManufacture date and expiry are printed on the vial label alongside the lot number.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eScientific references\u003c\/h2\u003e\n\u003cp\u003ePublished literature is indexed here for scientific reference. Citation does not indicate that this material is intended for, or suitable for, any use described in these papers.\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003eSikiric P, et al. Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract. \u003cem\u003eCurrent Pharmaceutical Design\u003c\/em\u003e. 2011;17(16):1612–1632. PMID 21548867. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21548867\/\" target=\"_blank\" rel=\"noopener nofollow\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/21548867\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eChang CH, et al. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. \u003cem\u003eJournal of Applied Physiology\u003c\/em\u003e. 2011;110(3):774–780. PMID 21030672. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21030672\/\" target=\"_blank\" rel=\"noopener nofollow\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/21030672\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eVukojevic J, et al. Pentadecapeptide BPC 157 and the central nervous system. \u003cem\u003eNeural Regeneration Research\u003c\/em\u003e. 2022;17(3):482–487. PMID 34380875. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34380875\/\" target=\"_blank\" rel=\"noopener nofollow\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/34380875\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eBilic Z, et al. Novel insight into Robert's cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. \u003cem\u003eJournal of Physiology and Pharmacology\u003c\/em\u003e. 2021;72(6). PMID 35485358. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35485358\/\" target=\"_blank\" rel=\"noopener nofollow\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/35485358\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eHe L, et al. Pharmacokinetics, distribution, metabolism, and excretion of body-protective compound 157, a potential drug for treating various wounds, in rats and dogs. \u003cem\u003eFrontiers in Pharmacology\u003c\/em\u003e. 2022;13:1026182. PMID 36588717. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36588717\/\" target=\"_blank\" rel=\"noopener nofollow\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/36588717\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"Puritas Lab","offers":[{"title":"Default Title","offer_id":50892719325220,"sku":"PUR-BPC-5","price":129.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0793\/7363\/1524\/files\/puritas-bpc157-5mg-v2.png?v=1785803353"},{"product_id":"ghk-cu-50-mg","title":"GHK-Cu — 50 mg","description":"\u003ch2\u003eWhat is GHK-Cu\u003c\/h2\u003e\n\u003cp\u003eGHK-Cu is the copper(II) complex of the tripeptide glycyl-L-histidyl-L-lysine, formed at 1:1 stoichiometry. The free tripeptide was isolated from human plasma in the 1970s; the copper complex is the form that carries the compound's characteristic chemistry and its blue color. Copper is held in a square-planar arrangement by the glycine α-amino nitrogen, the deprotonated backbone amide nitrogen, and the histidine imidazole nitrogen, with the lysine side chain remaining free.\u003c\/p\u003e\n\u003cp\u003eBecause the affinity is high but not absolute, GHK-Cu functions in solution as a copper-exchange system rather than a fixed molecule. That is what makes it a useful reagent: it is one of the standard tools for delivering copper(II) into a cell culture system in a defined, non-toxic coordination environment, and for studying how copper availability influences transcription. Reported plasma concentrations of the free peptide decline with donor age, which is why GHK appears frequently in comparative gene-expression datasets. Analytically, the complex is a common subject of stability work, since dissociation, oxidation state, and pH are all coupled.\u003c\/p\u003e\n\u003ch2\u003eResearch applications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eCopper-peptide complex stability and dissociation-constant studies across pH and ionic strength\u003c\/li\u003e\n\u003cli\u003eCopper delivery and cellular copper homeostasis modeling in fibroblast and keratinocyte culture\u003c\/li\u003e\n\u003cli\u003eGene expression profiling and transcriptomic response studies in copper-supplemented culture media\u003c\/li\u003e\n\u003cli\u003eExtracellular matrix protein synthesis assays in dermal fibroblast models\u003c\/li\u003e\n\u003cli\u003eMetalloprotein and metal-ligand coordination chemistry as a reference complex for UV-Vis and EPR characterization\u003c\/li\u003e\n\u003cli\u003eICP-MS and HPLC method development for metal-peptide complex quantitation and stoichiometry confirmation\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eVerification\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eEvery lot is tested twice, by two labs, and you can pull the results yourself.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePuritas synthesizes and compounds in its own Florida facility. Domestic synthesis is not a shipping-speed feature. It is control of the contamination chain — we know what went into the reactor, who ran the lyophilizer, and what the room was doing at the time.\u003c\/p\u003e\n\u003cp\u003eEvery lot goes to two independent laboratories:\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003eA US laboratory accredited to ISO\/IEC 17025 for the full analytical panel.\u003c\/li\u003e\n\u003cli\u003eJanoshik Analytical, whose results are published to a public lookup portal.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003eThe lot number is printed on the vial label. Enter it at the testing lab's own portal and the report loads from their database, under their control, with their timestamp.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWe don't host our COAs. Verify them at the lab.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eA hosted PDF is a file a vendor can edit. A record in an accredited lab's system is not.\u003c\/p\u003e\n\u003ch3\u003eThe panel we publish for every lot\u003c\/h3\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eTest\u003c\/th\u003e\n\u003cth\u003eMethod\u003c\/th\u003e\n\u003cth\u003eWhat gets published\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eIdentity\u003c\/td\u003e\n\u003ctd\u003eLC-MS\u003c\/td\u003e\n\u003ctd\u003eMeasured monoisotopic \/ average mass against theoretical\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePurity\u003c\/td\u003e\n\u003ctd\u003eRP-HPLC, UV area normalization\u003c\/td\u003e\n\u003ctd\u003eChromatogram plus numeric % main peak\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSecondary structure \/ functional group confirmation\u003c\/td\u003e\n\u003ctd\u003eFTIR\u003c\/td\u003e\n\u003ctd\u003eSpectrum\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFill accuracy\u003c\/td\u003e\n\u003ctd\u003eGravimetric, per-vial\u003c\/td\u003e\n\u003ctd\u003eMeasured mg, not \"as labeled\"\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEndotoxin\u003c\/td\u003e\n\u003ctd\u003eKinetic chromogenic LAL, USP \u0026lt;85\u0026gt;\u003c\/td\u003e\n\u003ctd\u003eEU\/vial as a number\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHeavy metals\u003c\/td\u003e\n\u003ctd\u003eICP-MS, USP \u0026lt;232\u0026gt;\u003c\/td\u003e\n\u003ctd\u003eMeasured values in ppm for each element, not \"complies\"\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eResidual solvents\u003c\/td\u003e\n\u003ctd\u003eGC-HS\u003c\/td\u003e\n\u003ctd\u003eMeasured values\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWater content\u003c\/td\u003e\n\u003ctd\u003eKarl Fischer\u003c\/td\u003e\n\u003ctd\u003e% w\/w\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCounterion \/ residual TFA\u003c\/td\u003e\n\u003ctd\u003eIon chromatography\u003c\/td\u003e\n\u003ctd\u003e% w\/w after acetate salt exchange\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eFill accuracy and endotoxin are the two numbers most vendors omit. A vial can be 99.4% pure and contain 7.1 mg where the label says 10 mg. Purity is a ratio. Fill is a quantity. They are different failures and we report both.\u003c\/p\u003e\n\u003ch3\u003eFailures stay up\u003c\/h3\u003e\n\u003cp\u003eIf a lot fails specification, the failed report is published with the failure marked, and the lot is destroyed rather than sold. We do not delete reports. We do not renumber lots. We do not requalify a failed lot under a new number. The archive is append-only, and older lots remain retrievable after they sell out.\u003c\/p\u003e\n\u003cp\u003eIf a report you expect to find is missing, that is a defect on our side. Send us the lot number.\u003c\/p\u003e\n\u003ch2\u003eThe Bad Vial Guarantee\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eIf it doesn't reconstitute clear, we replace it or refund it.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSend a photograph of the vial with the lot number legible. That is the entire process. There is no appeal, no review board, no restocking fee, no requirement that you return the vial, and no requirement that you explain what you were doing.\u003c\/p\u003e\n\u003cp\u003eThe guarantee covers:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCloudy, hazy, particulate, or discolored solution on reconstitution.\u003c\/strong\u003e Replacement or refund, your choice.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCracked, chipped, or leaking vials.\u003c\/strong\u003e Same terms.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCompromised stopper or seal, or a vacuum that has failed.\u003c\/strong\u003e Same terms.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBroken in transit.\u003c\/strong\u003e Photograph the package and the contents. Same terms.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLost in transit.\u003c\/strong\u003e If tracking shows no movement for seven days, or shows delivered and it was not, we reship. We do not require a carrier investigation to close first.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAssay disagreement.\u003c\/strong\u003e If you run the material and your numbers materially disagree with the published lot report, send us your data. We will retest and, if you are right, refund the lot, publish the correction, and pull remaining stock.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThere is no time window shorter than the product's shelf life. There is no limit on how many times you can claim. If we conclude a customer is claiming in bad faith we will stop selling to them, and we will say so directly rather than quietly denying claims.\u003c\/p\u003e\n\u003cp\u003eWe would rather eat the cost of a vial than argue about one.\u003c\/p\u003e\n\u003ch2\u003eStorage \u0026amp; handling\u003c\/h2\u003e\n\u003ch3\u003eLyophilized material, sealed vial\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eLong-term: −20 °C, desiccated, protected from light.\u003c\/li\u003e\n\u003cli\u003eShort-term and in-transit: 2–8 °C is acceptable. Ambient exposure during shipping does not compromise a lyophilized peptide over normal transit intervals; these compounds are shipped without cold chain by every laboratory supplier for this reason.\u003c\/li\u003e\n\u003cli\u003eKeep the vial sealed until use. Lyophilized peptide is hygroscopic and water uptake is the primary degradation pathway for dry material.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eAfter reconstitution\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e2–8 °C, protected from light.\u003c\/li\u003e\n\u003cli\u003eDo not freeze-thaw repeatedly. If material must be held long-term in solution, aliquot once and freeze the aliquots at −20 °C or below.\u003c\/li\u003e\n\u003cli\u003eDiscard any solution that develops haze, particulate, color change, or visible precipitate.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eAllow vials to equilibrate to room temperature before opening to avoid condensation onto the dry cake.\u003c\/li\u003e\n\u003cli\u003eDo not vortex or sonicate peptide solutions aggressively. Mechanical shear and foaming drive aggregation.\u003c\/li\u003e\n\u003cli\u003eWork under conditions appropriate to the endotoxin specification you require. Our EU\/vial figure describes the material as shipped, not the material after it has been through your bench.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eShelf life\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e36 months from date of manufacture, lyophilized, at −20 °C.\u003c\/li\u003e\n\u003cli\u003e24 months from date of manufacture, lyophilized, at 2–8 °C.\u003c\/li\u003e\n\u003cli\u003eManufacture date and expiry are printed on the vial label alongside the lot number.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eScientific references\u003c\/h2\u003e\n\u003cp\u003ePublished literature is indexed here for scientific reference. Citation does not indicate that this material is intended for, or suitable for, any use described in these papers.\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003eMaquart FX, et al. Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu²⁺. \u003cem\u003eFEBS Letters\u003c\/em\u003e. 1988;238(2):343–346. PMID 3169264. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/3169264\/\" target=\"_blank\" rel=\"noopener nofollow\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/3169264\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003ePickart L, Vasquez-Soltero JM, Margolina A. GHK and DNA: resetting the human genome to health. \u003cem\u003eBioMed Research International\u003c\/em\u003e. 2014;2014:151479. PMID 25302294. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25302294\/\" target=\"_blank\" rel=\"noopener nofollow\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/25302294\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003ePickart L, Vasquez-Soltero JM, Margolina A. GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. \u003cem\u003eBioMed Research International\u003c\/em\u003e. 2015;2015:648108. PMID 26236730. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26236730\/\" target=\"_blank\" rel=\"noopener nofollow\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/26236730\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003ePickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. \u003cem\u003eInternational Journal of Molecular Sciences\u003c\/em\u003e. 2018;19(7):1987. PMID 29986520. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29986520\/\" target=\"_blank\" rel=\"noopener nofollow\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/29986520\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"Puritas Lab","offers":[{"title":"Default Title","offer_id":50892719423524,"sku":"PUR-GHK-50","price":69.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0793\/7363\/1524\/files\/puritas-ghk-cu-50mg.png?v=1785803129"},{"product_id":"semax-30-mg","title":"Semax — 30 mg","description":"\u003ch2\u003eWhat is Semax\u003c\/h2\u003e\n\u003cp\u003eSemax is a synthetic heptapeptide developed in the Soviet Union and later registered as a pharmaceutical in Russia. Its first four residues, Met-Glu-His-Phe, reproduce the 4–7 fragment of adrenocorticotropic hormone. The remaining three, Pro-Gly-Pro, are not part of the ACTH sequence. They were appended specifically to slow enzymatic clearance, and they do — though the parent peptide's plasma half-life is still measured in minutes, because the N-terminal methionine is readily removed by aminopeptidases.\u003c\/p\u003e\n\u003cp\u003eThat design makes Semax a useful object of study in two directions at once. As an ACTH fragment analog it retains the melanocortin-derived sequence while lacking the corticotropic portion of the parent hormone, which allows the two functions to be separated in receptor and gene-expression models. As a prodrug-like structure it generates Pro-Gly-Pro, a fragment with its own documented activity and a longer tissue residence than the intact peptide, so metabolite chemistry is an experimental variable rather than a nuisance. Most published mechanistic work is transcriptomic, examining expression changes in rat brain tissue and cultured glial preparations.\u003c\/p\u003e\n\u003ch2\u003eResearch applications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eNeurotrophin gene expression assays (BDNF, NGF) in cultured glial and neuronal preparations\u003c\/li\u003e\n\u003cli\u003eBDNF\/TrkB signaling pathway modeling in hippocampal tissue preparations\u003c\/li\u003e\n\u003cli\u003eGenome-wide transcriptional profiling of immune and vascular gene response in rodent focal ischemia models\u003c\/li\u003e\n\u003cli\u003eMelanocortin receptor binding and selectivity studies against full-length ACTH reference standards\u003c\/li\u003e\n\u003cli\u003ePeptide metabolism studies characterizing aminopeptidase cleavage kinetics and Pro-Gly-Pro fragment generation\u003c\/li\u003e\n\u003cli\u003eMethionine oxidation and stability-indicating HPLC method development for sulfur-containing peptides\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eVerification\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eEvery lot is tested twice, by two labs, and you can pull the results yourself.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePuritas synthesizes and compounds in its own Florida facility. Domestic synthesis is not a shipping-speed feature. It is control of the contamination chain — we know what went into the reactor, who ran the lyophilizer, and what the room was doing at the time.\u003c\/p\u003e\n\u003cp\u003eEvery lot goes to two independent laboratories:\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003eA US laboratory accredited to ISO\/IEC 17025 for the full analytical panel.\u003c\/li\u003e\n\u003cli\u003eJanoshik Analytical, whose results are published to a public lookup portal.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003eThe lot number is printed on the vial label. Enter it at the testing lab's own portal and the report loads from their database, under their control, with their timestamp.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWe don't host our COAs. Verify them at the lab.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eA hosted PDF is a file a vendor can edit. A record in an accredited lab's system is not.\u003c\/p\u003e\n\u003ch3\u003eThe panel we publish for every lot\u003c\/h3\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eTest\u003c\/th\u003e\n\u003cth\u003eMethod\u003c\/th\u003e\n\u003cth\u003eWhat gets published\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eIdentity\u003c\/td\u003e\n\u003ctd\u003eLC-MS\u003c\/td\u003e\n\u003ctd\u003eMeasured monoisotopic \/ average mass against theoretical\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePurity\u003c\/td\u003e\n\u003ctd\u003eRP-HPLC, UV area normalization\u003c\/td\u003e\n\u003ctd\u003eChromatogram plus numeric % main peak\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSecondary structure \/ functional group confirmation\u003c\/td\u003e\n\u003ctd\u003eFTIR\u003c\/td\u003e\n\u003ctd\u003eSpectrum\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFill accuracy\u003c\/td\u003e\n\u003ctd\u003eGravimetric, per-vial\u003c\/td\u003e\n\u003ctd\u003eMeasured mg, not \"as labeled\"\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEndotoxin\u003c\/td\u003e\n\u003ctd\u003eKinetic chromogenic LAL, USP \u0026lt;85\u0026gt;\u003c\/td\u003e\n\u003ctd\u003eEU\/vial as a number\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHeavy metals\u003c\/td\u003e\n\u003ctd\u003eICP-MS, USP \u0026lt;232\u0026gt;\u003c\/td\u003e\n\u003ctd\u003eMeasured values in ppm for each element, not \"complies\"\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eResidual solvents\u003c\/td\u003e\n\u003ctd\u003eGC-HS\u003c\/td\u003e\n\u003ctd\u003eMeasured values\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWater content\u003c\/td\u003e\n\u003ctd\u003eKarl Fischer\u003c\/td\u003e\n\u003ctd\u003e% w\/w\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCounterion \/ residual TFA\u003c\/td\u003e\n\u003ctd\u003eIon chromatography\u003c\/td\u003e\n\u003ctd\u003e% w\/w after acetate salt exchange\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eFill accuracy and endotoxin are the two numbers most vendors omit. A vial can be 99.4% pure and contain 7.1 mg where the label says 10 mg. Purity is a ratio. Fill is a quantity. They are different failures and we report both.\u003c\/p\u003e\n\u003ch3\u003eFailures stay up\u003c\/h3\u003e\n\u003cp\u003eIf a lot fails specification, the failed report is published with the failure marked, and the lot is destroyed rather than sold. We do not delete reports. We do not renumber lots. We do not requalify a failed lot under a new number. The archive is append-only, and older lots remain retrievable after they sell out.\u003c\/p\u003e\n\u003cp\u003eIf a report you expect to find is missing, that is a defect on our side. Send us the lot number.\u003c\/p\u003e\n\u003ch2\u003eThe Bad Vial Guarantee\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eIf it doesn't reconstitute clear, we replace it or refund it.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSend a photograph of the vial with the lot number legible. That is the entire process. There is no appeal, no review board, no restocking fee, no requirement that you return the vial, and no requirement that you explain what you were doing.\u003c\/p\u003e\n\u003cp\u003eThe guarantee covers:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCloudy, hazy, particulate, or discolored solution on reconstitution.\u003c\/strong\u003e Replacement or refund, your choice.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCracked, chipped, or leaking vials.\u003c\/strong\u003e Same terms.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCompromised stopper or seal, or a vacuum that has failed.\u003c\/strong\u003e Same terms.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBroken in transit.\u003c\/strong\u003e Photograph the package and the contents. Same terms.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLost in transit.\u003c\/strong\u003e If tracking shows no movement for seven days, or shows delivered and it was not, we reship. We do not require a carrier investigation to close first.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAssay disagreement.\u003c\/strong\u003e If you run the material and your numbers materially disagree with the published lot report, send us your data. We will retest and, if you are right, refund the lot, publish the correction, and pull remaining stock.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThere is no time window shorter than the product's shelf life. There is no limit on how many times you can claim. If we conclude a customer is claiming in bad faith we will stop selling to them, and we will say so directly rather than quietly denying claims.\u003c\/p\u003e\n\u003cp\u003eWe would rather eat the cost of a vial than argue about one.\u003c\/p\u003e\n\u003ch2\u003eStorage \u0026amp; handling\u003c\/h2\u003e\n\u003ch3\u003eLyophilized material, sealed vial\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eLong-term: −20 °C, desiccated, protected from light.\u003c\/li\u003e\n\u003cli\u003eShort-term and in-transit: 2–8 °C is acceptable. Ambient exposure during shipping does not compromise a lyophilized peptide over normal transit intervals; these compounds are shipped without cold chain by every laboratory supplier for this reason.\u003c\/li\u003e\n\u003cli\u003eKeep the vial sealed until use. Lyophilized peptide is hygroscopic and water uptake is the primary degradation pathway for dry material.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eAfter reconstitution\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e2–8 °C, protected from light.\u003c\/li\u003e\n\u003cli\u003eDo not freeze-thaw repeatedly. If material must be held long-term in solution, aliquot once and freeze the aliquots at −20 °C or below.\u003c\/li\u003e\n\u003cli\u003eDiscard any solution that develops haze, particulate, color change, or visible precipitate.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eAllow vials to equilibrate to room temperature before opening to avoid condensation onto the dry cake.\u003c\/li\u003e\n\u003cli\u003eDo not vortex or sonicate peptide solutions aggressively. Mechanical shear and foaming drive aggregation.\u003c\/li\u003e\n\u003cli\u003eWork under conditions appropriate to the endotoxin specification you require. Our EU\/vial figure describes the material as shipped, not the material after it has been through your bench.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eShelf life\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e36 months from date of manufacture, lyophilized, at −20 °C.\u003c\/li\u003e\n\u003cli\u003e24 months from date of manufacture, lyophilized, at 2–8 °C.\u003c\/li\u003e\n\u003cli\u003eManufacture date and expiry are printed on the vial label alongside the lot number.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eScientific references\u003c\/h2\u003e\n\u003cp\u003ePublished literature is indexed here for scientific reference. Citation does not indicate that this material is intended for, or suitable for, any use described in these papers.\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003eShadrina MI, et al. Rapid induction of neurotrophin mRNAs in rat glial cell cultures by Semax, an adrenocorticotropic hormone analog. \u003cem\u003eNeuroscience Letters\u003c\/em\u003e. 2001;308(2):115–118. PMID 11457573. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11457573\/\" target=\"_blank\" rel=\"noopener nofollow\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/11457573\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eDolotov OV, et al. Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. \u003cem\u003eBrain Research\u003c\/em\u003e. 2006;1117(1):54–60. PMID 16996037. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16996037\/\" target=\"_blank\" rel=\"noopener nofollow\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/16996037\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eMedvedeva EV, et al. The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis. \u003cem\u003eBMC Genomics\u003c\/em\u003e. 2014;15:228. PMID 24661604. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24661604\/\" target=\"_blank\" rel=\"noopener nofollow\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/24661604\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eMedvedeva EV, et al. Semax, an analog of ACTH(4-7), regulates expression of immune response genes during ischemic brain injury in rats. \u003cem\u003eMolecular Genetics and Genomics\u003c\/em\u003e. 2017;292(3):635–653. PMID 28255762. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28255762\/\" target=\"_blank\" rel=\"noopener nofollow\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/28255762\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"Puritas Lab","offers":[{"title":"Default Title","offer_id":50892719456292,"sku":"PUR-SEM-30","price":89.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0793\/7363\/1524\/files\/puritas-semax-30mg-v2.png?v=1785803353"},{"product_id":"rta-10-mg-glp-3","title":"Retatrutide — Triple Agonist","description":"\u003ch2\u003eWhat is retatrutide\u003c\/h2\u003e\n\u003cp\u003eRetatrutide, developed as LY3437943, is a synthetic 39-amino-acid peptide built on a GIP-derived backbone and engineered to engage three incretin and glucagon-family receptors at once: the glucose-dependent insulinotropic polypeptide receptor, the glucagon-like peptide-1 receptor, and the glucagon receptor. Three non-coded residues carry the design. Aib at position 2 blocks dipeptidyl peptidase-4 cleavage. α-Methyl-L-leucine at position 13 and Aib at position 20 tune relative receptor potency and stability. A C20 fatty diacid is conjugated to Lys17 through a γGlu–AEEA linker, producing reversible albumin binding and the extended circulating half-life reported in phase 1 characterization.\u003c\/p\u003e\n\u003cp\u003eThe community taxonomy for this class is \"GLP-3.\" There is no GLP-3 receptor. The shorthand is buyer vocabulary for triple agonists, retained here once because that is the term people search — not because it describes a receptor.\u003c\/p\u003e\n\u003cp\u003eFor researchers, the value of the molecule is that it separates three signaling arms that are normally studied one at a time. It is a single chemical entity that lets a comparative pharmacology model hold peptide backbone constant while varying which receptor is blocked.\u003c\/p\u003e\n\u003ch2\u003eResearch applications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eGIP, GLP-1, and glucagon receptor-mediated cAMP accumulation assays in transfected cell lines\u003c\/li\u003e\n\u003cli\u003eβ-arrestin recruitment and receptor internalization studies for biased-agonism characterization\u003c\/li\u003e\n\u003cli\u003eComparative receptor-selectivity profiling against mono- and dual-agonist reference peptides\u003c\/li\u003e\n\u003cli\u003eAlbumin-binding and plasma protein interaction studies of C20 fatty diacid conjugates\u003c\/li\u003e\n\u003cli\u003eIn vitro DPP-4 resistance modeling of Aib-substituted incretin backbones\u003c\/li\u003e\n\u003cli\u003eAnalytical method development: LC-MS\/MS quantitation and HPLC stability-indicating method validation for lipidated peptides\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eVerification\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eEvery lot is tested twice, by two labs, and you can pull the results yourself.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePuritas synthesizes and compounds in its own Florida facility. Domestic synthesis is not a shipping-speed feature. It is control of the contamination chain — we know what went into the reactor, who ran the lyophilizer, and what the room was doing at the time.\u003c\/p\u003e\n\u003cp\u003eEvery lot goes to two independent laboratories:\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003eA US laboratory accredited to ISO\/IEC 17025 for the full analytical panel.\u003c\/li\u003e\n\u003cli\u003eJanoshik Analytical, whose results are published to a public lookup portal.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003eThe lot number is printed on the vial label. Enter it at the testing lab's own portal and the report loads from their database, under their control, with their timestamp.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWe don't host our COAs. Verify them at the lab.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eA hosted PDF is a file a vendor can edit. A record in an accredited lab's system is not.\u003c\/p\u003e\n\u003ch3\u003eThe panel we publish for every lot\u003c\/h3\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eTest\u003c\/th\u003e\n\u003cth\u003eMethod\u003c\/th\u003e\n\u003cth\u003eWhat gets published\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eIdentity\u003c\/td\u003e\n\u003ctd\u003eLC-MS\u003c\/td\u003e\n\u003ctd\u003eMeasured monoisotopic \/ average mass against theoretical\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePurity\u003c\/td\u003e\n\u003ctd\u003eRP-HPLC, UV area normalization\u003c\/td\u003e\n\u003ctd\u003eChromatogram plus numeric % main peak\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSecondary structure \/ functional group confirmation\u003c\/td\u003e\n\u003ctd\u003eFTIR\u003c\/td\u003e\n\u003ctd\u003eSpectrum\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFill accuracy\u003c\/td\u003e\n\u003ctd\u003eGravimetric, per-vial\u003c\/td\u003e\n\u003ctd\u003eMeasured mg, not \"as labeled\"\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEndotoxin\u003c\/td\u003e\n\u003ctd\u003eKinetic chromogenic LAL, USP \u0026lt;85\u0026gt;\u003c\/td\u003e\n\u003ctd\u003eEU\/vial as a number\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHeavy metals\u003c\/td\u003e\n\u003ctd\u003eICP-MS, USP \u0026lt;232\u0026gt;\u003c\/td\u003e\n\u003ctd\u003eMeasured values in ppm for each element, not \"complies\"\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eResidual solvents\u003c\/td\u003e\n\u003ctd\u003eGC-HS\u003c\/td\u003e\n\u003ctd\u003eMeasured values\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWater content\u003c\/td\u003e\n\u003ctd\u003eKarl Fischer\u003c\/td\u003e\n\u003ctd\u003e% w\/w\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCounterion \/ residual TFA\u003c\/td\u003e\n\u003ctd\u003eIon chromatography\u003c\/td\u003e\n\u003ctd\u003e% w\/w after acetate salt exchange\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eFill accuracy and endotoxin are the two numbers most vendors omit. A vial can be 99.4% pure and contain 7.1 mg where the label says 10 mg. Purity is a ratio. Fill is a quantity. They are different failures and we report both.\u003c\/p\u003e\n\u003ch3\u003eFailures stay up\u003c\/h3\u003e\n\u003cp\u003eIf a lot fails specification, the failed report is published with the failure marked, and the lot is destroyed rather than sold. We do not delete reports. We do not renumber lots. We do not requalify a failed lot under a new number. The archive is append-only, and older lots remain retrievable after they sell out.\u003c\/p\u003e\n\u003cp\u003eIf a report you expect to find is missing, that is a defect on our side. Send us the lot number.\u003c\/p\u003e\n\u003ch2\u003eThe Bad Vial Guarantee\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eIf it doesn't reconstitute clear, we replace it or refund it.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSend a photograph of the vial with the lot number legible. That is the entire process. There is no appeal, no review board, no restocking fee, no requirement that you return the vial, and no requirement that you explain what you were doing.\u003c\/p\u003e\n\u003cp\u003eThe guarantee covers:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCloudy, hazy, particulate, or discolored solution on reconstitution.\u003c\/strong\u003e Replacement or refund, your choice.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCracked, chipped, or leaking vials.\u003c\/strong\u003e Same terms.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCompromised stopper or seal, or a vacuum that has failed.\u003c\/strong\u003e Same terms.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBroken in transit.\u003c\/strong\u003e Photograph the package and the contents. Same terms.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLost in transit.\u003c\/strong\u003e If tracking shows no movement for seven days, or shows delivered and it was not, we reship. We do not require a carrier investigation to close first.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAssay disagreement.\u003c\/strong\u003e If you run the material and your numbers materially disagree with the published lot report, send us your data. We will retest and, if you are right, refund the lot, publish the correction, and pull remaining stock.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThere is no time window shorter than the product's shelf life. There is no limit on how many times you can claim. If we conclude a customer is claiming in bad faith we will stop selling to them, and we will say so directly rather than quietly denying claims.\u003c\/p\u003e\n\u003cp\u003eWe would rather eat the cost of a vial than argue about one.\u003c\/p\u003e\n\u003ch2\u003eStorage \u0026amp; handling\u003c\/h2\u003e\n\u003ch3\u003eLyophilized material, sealed vial\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eLong-term: −20 °C, desiccated, protected from light.\u003c\/li\u003e\n\u003cli\u003eShort-term and in-transit: 2–8 °C is acceptable. Ambient exposure during shipping does not compromise a lyophilized peptide over normal transit intervals; these compounds are shipped without cold chain by every laboratory supplier for this reason.\u003c\/li\u003e\n\u003cli\u003eKeep the vial sealed until use. Lyophilized peptide is hygroscopic and water uptake is the primary degradation pathway for dry material.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eAfter reconstitution\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e2–8 °C, protected from light.\u003c\/li\u003e\n\u003cli\u003eDo not freeze-thaw repeatedly. If material must be held long-term in solution, aliquot once and freeze the aliquots at −20 °C or below.\u003c\/li\u003e\n\u003cli\u003eDiscard any solution that develops haze, particulate, color change, or visible precipitate.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eAllow vials to equilibrate to room temperature before opening to avoid condensation onto the dry cake.\u003c\/li\u003e\n\u003cli\u003eDo not vortex or sonicate peptide solutions aggressively. Mechanical shear and foaming drive aggregation.\u003c\/li\u003e\n\u003cli\u003eWork under conditions appropriate to the endotoxin specification you require. Our EU\/vial figure describes the material as shipped, not the material after it has been through your bench.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eShelf life\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e36 months from date of manufacture, lyophilized, at −20 °C.\u003c\/li\u003e\n\u003cli\u003e24 months from date of manufacture, lyophilized, at 2–8 °C.\u003c\/li\u003e\n\u003cli\u003eManufacture date and expiry are printed on the vial label alongside the lot number.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eScientific references\u003c\/h2\u003e\n\u003cp\u003ePublished literature is indexed here for scientific reference. Citation does not indicate that this material is intended for, or suitable for, any use described in these papers.\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003eCoskun T, et al. LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept. \u003cem\u003eCell Metabolism\u003c\/em\u003e. 2022;34(9):1234–1247.e9. PMID 35985340. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35985340\/\" target=\"_blank\" rel=\"noopener nofollow\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/35985340\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eUrva S, et al. LY3437943, a novel triple GIP, GLP-1, and glucagon receptor agonist in people with type 2 diabetes: a phase 1b, multicentre, double-blind, placebo-controlled, randomised, multiple-ascending dose trial. \u003cem\u003eLancet\u003c\/em\u003e. 2022;400(10366):1869–1881. PMID 36354040. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36354040\/\" target=\"_blank\" rel=\"noopener nofollow\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/36354040\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eJastreboff AM, et al. Triple-Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial. \u003cem\u003eNew England Journal of Medicine\u003c\/em\u003e. 2023;389(6):514–526. PMID 37366315. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37366315\/\" target=\"_blank\" rel=\"noopener nofollow\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/37366315\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eRosenstock J, et al. Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA. \u003cem\u003eLancet\u003c\/em\u003e. 2023;402(10401):529–544. PMID 37385280. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37385280\/\" target=\"_blank\" rel=\"noopener nofollow\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/37385280\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"Puritas Lab","offers":[{"title":"10mg","offer_id":50963427950628,"sku":"PUR-GLP3-10","price":109.0,"currency_code":"USD","in_stock":true},{"title":"20mg","offer_id":50963427983396,"sku":"PUR-GLP3-20","price":159.0,"currency_code":"USD","in_stock":true},{"title":"30mg","offer_id":50963428016164,"sku":"PUR-GLP3-30","price":199.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0793\/7363\/1524\/files\/puritas-retatrutide-10mg.png?v=1785803129"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0793\/7363\/1524\/collections\/puritas-group-four-compounds.png?v=1785817327","url":"https:\/\/puritaslab.com\/collections\/compounds.oembed","provider":"Puritas Lab","version":"1.0","type":"link"}